Support For Many Metadata Formats - Metadatics supports reading and writing ID3v1, ID3v2, MP4, Vorbis, APE, and ASF tags all from a variety of audio file types. Artwork can be extracted or resized either in a batch or individually.įile Rename - Generate directory structures and rename files based on metadata. Online Sources - Search for tags on MusicBrainz and album artwork on Google.Īlbum Artwork - Metadatics supports reading and writing multiple images per file. Replace text, remove characters from the beginning or end of a tag, generate number sequences, copy from tag-to-tag, and much more! Metadatics provides all you need to edit metadata with ease and flexibility.īatch Editing - Edit multiple files at once quickly and easily.įunctions - Metadatics has a number of built in function to quickly manipulate data. Lookup metadata from online sources, rename files based on metadata, or manipulate metadata using one of the many built in functions. The Metadatics software price is Free, or Freemium means you can truly enjoy the Metadatics. Versatile metadata editor and song manager for your Mac that. It supports batch editing of most common audio file. A free content package and metadata editor. Metatogger Metatogger is a tag editor allowing you to rename, tag and easily sort your MP3, FLAC, Ogg Vorbis, WMA and M4A files. It supports batch editing of most common audio file types including MP3, M4A, AIFF, WAV, FLAC, APE, OGG, WMA, and more. Metadatics is a powerful and advanced audio metadata editor. Metadatics is a powerful audio metadata editor for macOS which supports several file types, including but not limited to, MP3, M4A, AIFF, WAV, FLAC, APE, OGG, WMA. Late-stage hepatocellular carcinoma (HCC) usually has a low survival rate because of the high risk of metastases and the lack of an effective cure.Metadatics is a powerful and advanced audio metadata editor. Disulfiram (DSF) has copper (Cu)-dependent anticancer properties in vitro and in vivo. The present work aims to explore the anti-metastasis effects and molecular mechanisms of DSF/Cu on HCC cells both in vitro and in vivo. The results showed that DSF inhibited the proliferation, migration and invasion of HCC cells. Cu improved the anti-metastatic activity of DSF, while Cu alone had no effect. Furthermore, DSF/Cu inhibited both NF-κB and TGF-β signalling, including the nuclear translocation of NF-κB subunits and the expression of Smad4, leading to down-regulation of Snail and Slug, which contributed to phenotype epithelial-mesenchymal transition (EMT). Finally, DSF/Cu inhibited the lung metastasis of Hep3B cells not only in a subcutaneous tumour model but also in an orthotopic liver metastasis assay. These results indicated that DSF/Cu suppressed the metastasis and EMT of hepatic carcinoma through NF-κB and TGF-β signalling. Our study indicates the potential of DSF/Cu for therapeutic use.ĮMT TGF-β copper disulfiram metastasis. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.ĭSF/Cu inhibits the migration of Hep3B cells. ( A) Effect of DSF/Cu on the viability of hepatic carcinoma cells. Hep3B and HepG2 cells were incubated with increasing concentrations of DSF with or without Cu (1 and 0.1 μM) for 24 hrs. Cell viability was determined by MTT colorimetric assay. The percentage of viable cells was calculated by comparison to the absorption of control cells (0.1% DMSO), which was set as 100%. * P < 0.05, significantly different compared with the DMSO‐treated control. Data were compared by one‐way anova followed by Dunnett's test. ( B) A Real‐time measurement of the migration and invasion of Hep3B cells during 24 hrs treatment with DSF (6, 12 μM) with or without Cu (0.1 μM). It supports batch editing of most audio file types including MP3, M4A, AIFF, WAV, FLAC, APE, OGG, WMA, and more. Metadatics is a powerful audio metadata editor with many features. ( C) Scratch‐wound healing recovery assay following a 24‐hrs exposure of Hep3B cells to the indicated concentrations of DSF/Cu. Metadatics An Advanced Audio Metadata Editor For Mac OS X. The wound area was used to quantify the extent of wound healing in each group. The values obtained are expressed as a migration percentage, setting the gap area at 0 hr as 0%. * P < 0.05, significantly different compared with the control group # P < 0.05 versus the indicated groups. Comparisons were made by one‐way anova followed by Dunnett's test. The photographs were taken at the magnification of ×100.ĭSF/Cu represses TGF‐β1‐induced migration and regulates EMT in Hep3B cells.
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